ABSTRACT
Objective: To demonstrate that mild hypothermia can be a protective element when an ischemic onset occurs in rabbit brains. Methods: A rabbit model of focal ischemia was used to test the protection provided by mild hypothermia regionally produced by means of the placement of ice bag on the scalp of a hemicranium which has had previously its bone removed. Twenty New Zealand White rabbits were divided into two groups as follows: (A) a control group where an ischemic lesion was produced by coagulation of the middle cerebral artery and (B) a brain protected group where mild hypothermia was provided during 80 to 100 minutes after the same ischemic lesion. The brains slices were stained with 2,3,5-Triphenyletrazolium (TTC). The sections were photographed with a digital camera and the infarct volume was measured through a computer program. Results: The average of infarct volume was 70.53 mm3 in the control group. In the protected group, the average of infarct volume was 41,30 mm3 only in five animals. Five animals of this group did not demonstrate macroscopically and microscopically infarct area. Conclusions: We concluded that mild hypothermia regionally produced may protect ischemic brains of rabbits.
Subject(s)
Animals , Rabbits , Brain Ischemia , Hypothermia, Induced , Protective Factors , Brain Ischemia , Cerebral InfarctionABSTRACT
As lombalgias encontram-se presentes em uma grande parcela da população. Várias são as condições patológicas que podem estar acompanhadas de lombalgias crônicas. A decisão de quando tais casos devem ser encaminhados para a cirurgia nem sempre é tarefa fácil. São analisadas hérnias de disco lombares, as espôndilo-listeses de coluna lombar, a síndrome do canal estreito, a síndrome do disco degenerado e a osteoporose vertebral, cinco afecções freqüentes da clínica diária, que se acompanham de lombalgias crônicas e que, em determinadas circunstâncias, devem ser encaminhadas para tratamento cirúrgico. São sugeridas algumas condições ideais para este encaminhamento